The health informatics (HI) field is highly interdisciplinary and always evolving with rapid changes in health information technologies. The HI curricula shall be reviewed and updated regularly to meet workforce needs and equip graduates with essential knowledge and skills for career development and success. Existing synthesis on HI education has focused on core competencies and skills across general career pathways and mapping professional skills to a UK or Canadian HI healthcare context or frameworks. Since healthcare policy and industry vary in settings and countries, there is a gap in synthesizing HI education in the context of the United States (US) and capturing the demands and requirements of its unique healthcare industry. Therefore, this study addressed this gap by exploring two research questions (RQs). RQ1: What HI competencies and skills are specific to US HI industry jobs? RQ2: How well does the current HI education align with US industry requirements? The results from this study have informed our institutional HI curriculum updates for master’s-level degrees, providing insights for other programs regarding updating curricula to meet the healthcare industry demands.